Digital cholangioscopy (SpyglassTM) in the diagnosis of cholangiocarcinoma

Since 1970s the evaluation and treatment of bile duct lesions have been accomplished mostly by endoscopic retrograde cholangiopancreatography (ERCP). However, neither ERCP nor other imaging procedures (e.g., endoscopic ultrasound) allow for safe diagnosis of these lesions. Since the emergence of the fi beroptic SpyGlass Direct Visualization System (SDVS) (Boston Scientifi c, Natick, Massachusetts, USA) in 2006 the sensitivity for detecting cholangiocarcinoma has increased, thereby establishing its superiority over standard ERCP [1]. ERCP-guided cholangiopancreatoscopy with SDVS allows for direct visualization of the bile ducts, tissue sampling and therapeutic maneuvers [1,2]. Th e impediment of the initial fi beroptic technology has been overcome by the introduction of a new digital SDVS, providing sensitivity and specifi city of 90% and 95.8%, respectively, for visual impression of malignancy diagnosis [3]. A 51-year-old man was referred to our department due to painless obstructive jaundice for further evaluation with ERCP. He had undergone magnetic resonance cholangiopancreatography (MRCP) which had shown dilation of the common bile duct (CBD diameter ∼1.4 cm) and raised suspicion for stenosis in the lower part of CBD. He underwent an ERCP and endoscopic sphincterotomy. A stenosis in the lower part of CBD was observed. Brush cytology was performed, and a stent was placed in CBD. Th e patient was discharged due to clinical and laboratory improvement (brush cytology was negative for neoplasia). Fift een days later he was re-admitted for further evaluation and he underwent a second ERCP and digital choledochoscopy with SDVS which showed nodular mucosa with ulceration and mucin containing material in the lower part of CBD (Fig. 1), highly indicative of malignancy. Biopsies obtained under direct visualization from the lesion showed extensive fi brosis and focal infi ltration by moderately to poorly diff erentiated adenocarcinoma (Fig. 2). References